We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Liposomes with Caffeic Acid: Morphological and Structural Characterisation, Their Properties and Stability in Time.
- Authors
Dejeu, Ioana Lavinia; Vicaș, Laura Grațiela; Jurca, Tunde; Teușdea, Alin Cristian; Mureșan, Mariana Eugenia; Fritea, Luminița; Svera, Paula; Gabor, Gianina Adela; Dejeu, George Emanuiel; Maghiar, Octavian Adrian; Bodea, Anca Salomea; Pallag, Annamaria; Marian, Eleonora
- Abstract
Medical and pharmaceutical research has shown that liposomes are very efficient in transporting drugs to targets. In this study, we prepared six liposome formulas, three in which we entrapped caffeic acid (CA), and three with only phospholipids and without CA. Determination of entrapment efficiency (EE) showed that regardless of the phospholipids used, the percentage of CA entrapment was up to 76%. The characterization of the liposomes was performed using Dynamic Light Scattering (DLS), Atomic Force Microscopy (AFM), zeta potential and polydispersity and showed that about 75–99% of the liposomes had dimensions between 40 ± 0.55–500 ± 1.45 nm. The size and zeta potential of liposomes were influenced by the type of phospholipid used to obtain them. CA release from liposomes was performed using a six-cell Franz diffusion system, and it was observed that the release of entrapped CA occurs gradually, the highest amount occurring in the first eight hours (over 80%), after which the release is much reduced. Additionally, the time stability of the obtained liposomes was analysed using univariate and multivariate statistical analysis. Therefore, liposomes offer great potential in CA entrapment.
- Subjects
LIPOSOMES; CAFFEIC acid; MULTIVARIATE analysis; ATOMIC force microscopy; ZETA potential; LIGHT scattering; PHOSPHOLIPIDS
- Publication
Processes, 2021, Vol 9, Issue 6, p912
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr9060912