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- Title
Both Chloroquine and Lopinavir/Ritonavir Are Ineffective for COVID-19 Treatment and Combined Worsen the Pathology: A Single-Center Experience with Severely Ill Patients.
- Authors
Sevilla-Castillo, Fernando; Roque-Reyes, Oscar J.; Romero-Lechuga, Fernanda; Gómez-Núñez, Mario F.; Castillo-López, Mariel; Medina-Santos, Diana; Román, Perla Oriana; Flores-Hernández, Jorge Rafael; Méndez-Coca, Juan Daniel; Montaño-Olmos, Daniela; Farfán-Lazos, Karla Cecilia; Tobón-Cubillos, Miranda; Viveros-Hernández, América; Torres-Ortega, Leonardo; Hernández-Skewes, Karla Y.; Montiel-Bravo, Guillermo; Ortega-Rodríguez, Shannat; Peón, Alberto N.
- Abstract
The off-label use of antiviral and antimalarial drugs has been considered by many researchers as a fast and relatively safe alternative to provide therapeutic options to treat COVID-19, but the assessment of such drug-specific effectiveness in this regard is far from complete. Especially, the current body of knowledge about COVID-19 therapeutics needs more data regarding drug effectiveness and safety in the severely ill patients with comorbidities. In the present article, we retrospectively analyze data from 61 patients that received treatment with chloroquine, lopinavir/ritonavir, both drugs administered together, or a standard treatment with no antiviral drugs, and the study was carried in severely ill patients. We found that either drug is ineffective at treating COVID-19, as they are not able to reduce hospitalization length, mortality, C-reactive protein (CRP), lactate dehydrogenase (LDH), d-Dimer, or ferritin, or to enhance gasometric parameters, lymphocytes, total leukocytes, and neutrophil levels, whereas both drugs administered together decrease circulating lymphocytes, increase LDH and ferritin levels, and more importantly, enhance mortality. In this way, our results show that both drugs are ineffective and even potentially harmful alternatives against SARS-CoV-2.
- Subjects
C-reactive protein; CHLOROQUINE; CLINICAL trials; CRITICALLY ill; FERRITIN; LENGTH of stay in hospitals; LACTATE dehydrogenase; MORTALITY; PATIENTS; COMORBIDITY; TREATMENT effectiveness; RETROSPECTIVE studies; FIBRIN fibrinogen degradation products; LOPINAVIR-ritonavir; COVID-19
- Publication
BioMed Research International, 2021, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2021/8821318