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- Title
Relationship of HbA1c with Visual and Anatomical Outcomes of Bevacizumab in Diabetic Macular Edema.
- Authors
Zaka, Royala; Majid Khan, Burhan Abdul; Ahmed Sabri, Mirza Zaki-ud-Din; Qureshi, Rabia
- Abstract
Purpose: To find relationship of baseline Hemoglobin A1c (HbA1c) with visual outcomes, central macular thickness and number of intravitreal Bevacizumab at 12 months in patients with diabetic macular edema (DME). Study Design: Quasi experimental study. Place and Duration of Study: Prevention of blindness (POB) Hospital, Karachi, Pakistan between October 2018 and September 2019. Material and Methods: Two hundred and eighty patients with Diabetic macular edema (DME) presenting to the eye OPD of POB, who did not receive any treatment for DME were recruited. Patients who had concurrent retinal disease and were treated with intravitreal injections and/or laser were excluded. All patients were evaluated with history, ophthalmological examination and SD-OCT for central subfield macular thickness. Patients received 3 intravitreal injections of Bevacizumab one month apart. OCT was done after 3 months and retreatment for diabetic macular edema was based on the persistence of macular thickness more than 300 microns. All the data was analyzed using SPSS version 20. Results: There were 280 patients, 53.2% were males and 46.8% were females. Patients were divided into 3 groups; patients with HbA1C < 7.0, 7.1 - 8.0 and > 8.0. Central macular thickness decreased significantly from baseline in all 3 groups. Maximum vision improvement was seen in group 1 with HbA1C < 7.0 and group 2 with 7.1 - 8.0. Significant inverse correlation was seen between HbA1C and vision at 12 months (r = - 0.40, p < 0.01) and positive correlation with central macular thickness (r = 0.53 p < 0.01). Conclusion: Initial baseline HbA1C is strongly related with visual and anatomic outcome at 12 months.
- Subjects
GLYCOSYLATED hemoglobin; BEVACIZUMAB; DIABETIC retinopathy; EYE examination; RETINAL diseases
- Publication
Pakistan Journal of Ophthalmology, 2019, Vol 35, Issue 4, p258
- ISSN
0886-3067
- Publication type
Article