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- Title
Osseointegration of SLActive implants in diabetic pigs.
- Authors
Schlegel, K. A.; Prechtl, C.; Möst, T.; Seidl, C.; Lutz, R.; Wilmowsky, C.
- Abstract
Objectives Diabetes mellitus is currently classified as a relative contraindication for implant treatment because of microangiopathies with the consequence of impaired bone regeneration and higher rates of implant failure. The study aim was to investigate peri-implant bone formation in a diabetic animal model in comparison to healthy animals and to evaluate the differences between conventional ( SLA®) and modified ( SLActive®) titanium implant surfaces on osseointegration. Material and methods Each six implants were placed in the calvaria of 11 diabetic and 4 healthy domestic pigs. At 30 and 90 days after implant placement, the bone-to-implant contact ( BIC) and bone density ( BD) were appraised. Additionally, the expression of the bone-matrix proteins collagen type I and osteocalcin was evaluated at both points in time by using immunohistochemical staining methods. Results Overall, BIC was reduced in the diabetic group at 30 and 90 days. After 90 days, the SLActive® implants showed significantly higher BICs compared with the SLA® implants in diabetic animals. Peri-implant BD was higher in the SLActive® group at 30 and 90 days in healthy and diabetic animals. Collagen type I protein expression was higher using SLA® implants in diabetic pigs at 30 days. Values for osteocalcin expression were not consistent. Conclusions The results indicate the negative effect of untreated diabetes mellitus on early osseointegration of dental implants. The modified SLA® surface ( SLActive®) elicited an accelerated osseointegration of dental implants, suggesting that a better prognosis for implant treatment of diabetic patients is possible.
- Subjects
OSSEOINTEGRATION; DENTAL implants; DIABETES; LABORATORY swine; COLLAGEN; EXTRACELLULAR matrix proteins; GENE expression; IMMUNOHISTOCHEMISTRY
- Publication
Clinical Oral Implants Research, 2013, Vol 24, Issue 2, p128
- ISSN
0905-7161
- Publication type
Article
- DOI
10.1111/j.1600-0501.2011.02380.x