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- Title
Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non-metastatic carcinoma invading bladder muscle: results from a nationwide case-control study.
- Authors
Neuzillet, Yann; Soulie, Michel; Larre, Stéphane; Roupret, Morgan; Defortescu, Guillaume; Murez, Thibaut; Pignot, Géraldine; Descazeaud, Aurélien; Patard, Jean‐Jacques; Bigot, Pierre; Salomon, Laurent; Colin, Pierre; Rigaud, Jérôme; Bastide, Cyrille; Durand, Xavier; Valeri, Antoine; Kleinclauss, François; Bruyere, Franck; Pfister, Christian
- Abstract
What's known on the subject? and What does the study add? Positive surgical margin ( PSM) frequency after radical cystectomy has been estimated to be 4-15%. Studies that have not distinguished between the different sites of PSM have failed to show that they are an independent prognostic factor for disease-free survival. Only perivesical soft tissue PSMs have been associated with an increased risk of cancer recurrence and cancer-specific death., This is the first comprehensive published analysis of PSMs occurring during radical cystectomy for pTx pN0 M0 bladder cancer according to their location, comparing their cancer-specific survival ( CSS) and other outcomes with those of a control group paired according to TNM status, age, sex and urinary diversion method. Local recurrence-free survival rates were found to be lower in patients with both soft tissue and urethral PSMs. Moreover, soft-tissue PSMs were associated with lower metastatic recurrence-free and CSS rates., Objective To compare the prognoses associated with positive surgical margins ( PSMs) according to their urethral, ureteric and/or soft tissue locations in patients with pN0 M0 bladder cancer who have not undergone neoadjuvant chemotherapy., Patients and Methods A retrospective, case-control study was conducted between 1991 and 2011 using data from 17 academic centres in France., A total of 154 patients (cases) with PSMs met the eligibility criteria and were matched according to centre, p T stage, gender, age and urinary diversion method with a population-based sample of 154 patients (controls) from 3651 patients who had undergone cystectomies., The median follow-up period was 23.9 months., Multivariable Cox regression analysis was used to test the effects of PSMs on local recurrence ( LR)-free survival, metastatic recurrence ( MR)-free survival and cancer-specific survival ( CSS)., Results The 5-year LR-free survival and CSS rates of patients with urethral and soft tissue PSMs were lower than those in the control group., A significant decrease in CSS was associated with soft tissue PSMs ( P = 0.003, odds ratio = 0.425, 95% confidence interval 0.283-0.647). The prognosis was not affected in cases of ureteric PSMs., Conclusions Soft tissue PSMs were associated with poor CSS rates in patients with pN0 M0 bladder cancer., A correlation between urethrectomy and a reduction of the risk of LR in a urethral PSM setting was observed.
- Subjects
SURGICAL site; CARCINOMA; BLADDER cancer treatment; CASE-control method; CYSTOTOMY; CANCER relapse
- Publication
BJU International, 2013, Vol 111, Issue 8, p1253
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/j.1464-410X.2012.11664.x