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- Title
Selective bladder-sparing protocol consisting of induction low-dose chemoradiotherapy plus partial cystectomy with pelvic lymph node dissection against muscle-invasive bladder cancer: oncological outcomes of the initial 46 patients.
- Authors
Koga, Fumitaka; Kihara, Kazunori; Yoshida, Soichiro; Yokoyama, Minato; Saito, Kazutaka; Masuda, Hitoshi; Fujii, Yasuhisa; Kawakami, Satoru
- Abstract
Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? TURBT plus full-dose chemoradiotherapy (CRT) against MIBC allow more than 40% of patients to spare the bladder while maintaining survival outcomes comparable to those of radical cystectomy (RC) series, contributing to improvement of the patients' quality of life. Limitations of these protocols, however, include 1) MIBC recurrence in the preserved bladder mainly due to subclinical residual disease in the original MIBC site, 2) potential lack of curative intervention to regional lymph nodes and 3) increased mortality of salvage RC due to previous high-dose pelvic irradiation. We propose a novel selective bladder-sparing protocol consisting of induction low-dose CRT plus consolidative partial cystectomy with pelvic lymph node dissection, which potentially contributes to overcoming the limitations of the conventional bladder-sparing protocols. OBJECTIVE
- Subjects
BLADDER cancer; RADIOTHERAPY; MEDICAL protocols; CYSTS (Pathology); SURGERY; LYMPH nodes; PELVIC bones; HEALTH outcome assessment; QUALITY of life
- Publication
BJU International, 2012, Vol 109, Issue 6, p860
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/j.1464-410X.2011.10425.x