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- Title
Hypereozinofilie.
- Authors
J., Novotný
- Abstract
Hypereosinophilia (HE) and hypereosinophilic syndrome (HES) represent very polymorphic syndromes often involving very difficult differential dia gnosis. HES with serious end-organ damage must be treated promptly, especially in the presence of cardiac involvement. Parasitic infections are the most frequent cause of HE worldwide, yet they are rare in our latitudes. In developed countries, the main causes of HE include atopies (asthma, rhinitis, atopic dermatoses), drug reactions, autoagressive diseases and malignancies. In about 50% of patients with HES no specific cause is detected and these cases are termed idiopathic HES (iHES). High-dose corticosteroids represent the first-line therapy of severe HES, with promise being shown by bio logical treatments in the form of monoclonal antibodies (mepolizumab, reslizumab, benralizumab, alemtuzumab). Tyrosine-kinase inhibitors (TKI) are indicated in HE with proven aberrant tyrosine-kinase activity. Chronic eosinophilic leukaemia - not otherwise specified (CEL-NOS) requires a specific approach. Progress in research may in the near future help elucidate the specific cause of some iHES.
- Publication
Transfusiology & Haematology Today / Transfuze a Hematologie Dnes, 2021, Vol 27, Issue 4, p278
- ISSN
1213-5763
- Publication type
Article
- DOI
10.48095/cctahd2021278