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- Title
Real-life Data on Patient Characteristics, Cost and Effectiveness of Field- directed Treatment for Actinic Keratoses: An Observational Study.
- Authors
RIJSINGEN, Margit C. J. VAN; SEUBRING, Inge; GRUTTERS, Janneke P. C.; MAESSEN-VISCH, M. Birgitte; AL-KEMADE, Hans A. C.; VAN DOORN, Remco; GROENEWOUD, Hans; VAN DE KERKHOF, Peter C. M.; VAN DER WILT, Gert Jan; GERRITSEN, Marie-Jeanne P.
- Abstract
Actinic keratoses (AK) occur frequently; however, reallife clinical data on personalized treatment choice and costs are scarce. This multicentre one-year observational study investigated patient-characteristics, cost and effectiveness of methylaminolaevulinate photodynamic therapy (MAL-PDT), imiquimod (IMI) and 5-fluorouracil (5-FU) in patients with AKs on the face/scalp. A total of 104 patients preferred MAL-PDT, 106 preferred IMI and 110 preferred 5-FU. At baseline, significant differences between treatment groups were found; most patients were severely affected (mean 32.5 AK in PDT-group, 20.2 in IMI-group, 22.8 in 5-FU-group). A mean reduction in lesions of 81% after MAL-PDT, 82% after IMI and 88% after 5-FU was found after one year. Annual costs were €1,950 for MAL-PDT, €877 for IMI and €738 for 5-FU. These results show that, compared with clinical trials, in the real-life clinical setting AK patients are usually more severely affected and treatment costs are much higher. Furthermore, patient characteristics are important factors in treatment choice.
- Subjects
PHOTODYNAMIC therapy; ACTINIC keratosis; COST effectiveness; PATIENT compliance; DIAGNOSIS; THERAPEUTICS
- Publication
Acta Dermato-Venereologica, 2016, Vol 96, Issue 3, p346
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2216