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- Title
Modulation of cutaneous SP receptors in atopic dermatitis after UVA irradiation.
- Authors
Staniek, V.; Liebich, C.; Vocks, E.; Odia, S. G.; Doutremepuich, J. D.; Ring, J.; Claudy, A.; Schmitt, D.; Misery, L.
- Abstract
Atopic dermatitis is a pruritic inflammatory skin disorder, involving immunological and non-immunological factors. Substance P seems to be involved in the pathogenesis of atopic dermatitis. Substance P-containing nerve fibers are increased in the lesional skin of patients with atopic dermatitis and a reduced weal and flare reaction to intradermal injection of substance P has been observed. We investigated the distribution of substance P receptors in the involved skin of patients before and after single or repetitive UVA irradiations. Our results indicate that substance P receptors of the NK-1 subtype are expressed on blood vessels and on epidermal keratinocytes of involved skin of patients with atopic dermatitis. UVA irradiations did not modify the epidermal distribution of substance P receptors but decreased their expression intensity on blood vessels. UVA irradiations seem to decrease skin inflammation through the modulation of NK-1 receptor expression on endothelial cells.
- Subjects
SUBSTANCE P; ATOPIC dermatitis
- Publication
Acta Dermato-Venereologica, 1998, Vol 78, Issue 2, p92
- ISSN
0001-5555
- Publication type
Article
- DOI
10.1080/000155598433386