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- Title
Movement Disorders in Spinocerebellar Ataxias in a Cohort of Brazilian Patients.
- Authors
Moro, adriana; Munhoz, Renato P.; Moscovich, Mariana; arruda, Walter O.; Raskin, Salmo; Teive, Hélio a.G.
- Abstract
Background: Movement disorders (MDs) are well recognized in all subtypes of spinocerebellar ataxias (SCA), but phenomenology and frequency vary widely. Methods: Three hundred seventy-eight patients, from 169 Brazilian families, with SCAs were assessed with neurological examination and molecular genetic testing. Results: Dystonia was the most common movement disorder, found in 5.5% of all patients, particularly in SCA3. We observed Parkinsonian features in 6.6% of SCA3 patients, and myoclonus in two patients of our cohort. Conclusions: Our study demonstrated that MDs are major extracerebellar manifestations of SCA. The observed phenotypes in addition to ataxia may provide significant clues for a particular SCA genotype. © 2014 S. Karger AG, Basel
- Subjects
SPINOCEREBELLAR ataxia; CEREBELLAR ataxia; CEREBELLUM degeneration; SPINAL cord diseases; MOVEMENT disorders
- Publication
European Neurology, 2014, Vol 72, Issue 5/6, p360
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000365285