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- Title
Association Between the M268T Polymorphism in the Angiotensinogen Gene and Essential Hypertension in a South Indian Population.
- Authors
Gopi Chand, M.; Srinath, J.; Rao, R.; Lakkakula, Bhaskar; Kumar, Satish; Rao, V.
- Abstract
Essential hypertension is a complex multifactorial disease caused by interactions between genetic and environmental factors. It is an independent determinant of cardiovascular risk. The main aim of this study was to investigate the possible influence of angiotensinogen M268T polymorphisms on hypertension in two endogamous caste populations of South India. Systolic and diastolic blood pressure, anthropometric variables, and lipid profiles were assessed. Direct sequencing of PCR products was adopted for genotyping. This polymorphism was found to be in Hardy-Weinberg equilibrium in the patients and controls of both populations. Binary odds ratios showed significant association between the M268T polymorphism and hypertension in both populations. Multivariate analysis revealed significant differences in body mass index, chest girth, calf circumference, skinfold measurements, total cholesterol, and triglyceride levels between these genotypes in the Gavara and Vaishya populations. These data further support the hypothesis that hypertension is influenced by the AGT M268T polymorphism.
- Subjects
SOUTH India; GENETIC polymorphisms; ESSENTIAL hypertension; GENOTYPE-environment interaction; POLYMERASE chain reaction; MULTIVARIATE analysis; GAVARAS
- Publication
Biochemical Genetics, 2011, Vol 49, Issue 7/8, p474
- ISSN
0006-2928
- Publication type
Article
- DOI
10.1007/s10528-011-9423-y