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- Title
Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery.
- Authors
Bom Sahn Kim; Sang Soo Cho; Joon Young Choi; Young Hwan Kim; Kim, Bom Sahn; Cho, Sang Soo; Choi, Joon Young; Kim, Young Hwan
- Abstract
<bold>Purpose: </bold>Transient global amnesia (TGA) is characterized by sudden loss of memory of recent events, transient inability to retain new information, and retrograde amnesia. We investigated the changes of regional cerebral blood flow in patients with TGA shortly after symptom onset and after recovery using Tc-99m-ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m ECD SPECT) and statistical parametric mapping (SPM) analysis.<bold>Methods: </bold>Six right-handed patients with TGA were studied using Tc-99m ECD SPECT shortly after symptom onset and after recovery. As a control group, six healthy individuals were also studied. Images were analyzed using SPM8 using voxel-based analysis to estimate the differences between TGA patients and controls.<bold>Results: </bold>There was significant hypoperfusion in the left hippocampus, left thalamus, and bilateral cerebellum. In the follow-up SPECT scan, hypoperfusion in hippocampus and thalamus were restored, while hypoperfusion was noted in the temporoparietal region.<bold>Conclusion: </bold>Our results suggest that the underlying mechanism of TGA may be temporary ischemia in the hippocampus and thalamus. There was significant restoration of perfusion in the hippocampus and thalamus after recovery from TGA.
- Subjects
TRANSIENT global amnesia; CEREBRAL circulation; SINGLE-photon emission computed tomography; CONTROL groups; ISCHEMIA
- Publication
Diagnostic & Interventional Radiology, 2016, Vol 22, Issue 5, p476
- ISSN
1305-3825
- Publication type
journal article
- DOI
10.5152/dir.2016.15487