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- Title
Internet-based perioperative exercise program in patients with Barrett's carcinoma scheduled for esophagectomy [iPEP - study] a prospective randomized-controlled trial.
- Authors
Pfirrmann, Daniel; Suzan Tug; Brosteanu, Oana; Mehdorn, Matthias; Busse, Martin; Grimminger, Peter P.; Lordick, Florian; Glatz, Torben; Hoeppner, Jens; Hauke Lang; Simon, Perikles; Gockel, Ines; Tug, Suzan; Lang, Hauke
- Abstract
<bold>Background: </bold>Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence and reduced quality of life. Socioeconomic disadvantages can result from these problems. Physical preconditioning has become a crucial leverage to optimize fitness and lung function in patients scheduled for esophagectomy, in particular during the time period of neoadjuvant therapy.<bold>Methods/study Design: </bold>We designed a prospective multicenter randomized-controlled trial. The objective is to evaluate the impact of an internet-based exercise program on postoperative respiratory parameters and pneumonia rates in patients with Barrett's carcinoma scheduled for esophagectomy. Patients are randomly assigned to either execute internet-based perioperative exercise program (iPEP), including daily endurance, resistance and ventilation training or treatment as usual (TAU). During neoadjuvant therapy and recovery, patients in the intervention group receive an individually designed intensive exercise program based on functional measurements at baseline. Personal feedback of the supervisor with customized training programs is provided in weekly intervals.<bold>Discussion: </bold>This study will evaluate if an intensive individually adapted training program via online supervision during neoadjuvant therapy will improve cardiorespiratory fitness and reduce pulmonary complications following esophagectomy for Barrett's cancer.<bold>Trial Registration: </bold>NCT02478996 , registered 26 May 2015.
- Subjects
BARRETT'S esophagus; ESOPHAGECTOMY; EXERCISE physiology; PERIOPERATIVE care; ADJUVANT treatment of cancer; RANDOMIZED controlled trials; THERAPEUTICS; ESOPHAGEAL tumors; COMPARATIVE studies; DIGESTIVE organ surgery; EXERCISE; EXERCISE therapy; INTERNET; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; MEDICAL research; RESEARCH; PULMONARY function tests; TIME; EVALUATION research; TREATMENT effectiveness; TUMOR treatment
- Publication
BMC Cancer, 2017, Vol 17, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-017-3400-8