We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Leptomeningeal Carcinomatosis in a Krukenberg Tumor Associated with Signet Ring Cell Gastric Cancer.
- Authors
BAŞGÖZ, Bilgin Bahadır; YILDIZ, Birol; AYDIN, Adem; ERDEM, Gökhan; ASLAN, Harun; SAĞLAM, Kenan; ARPACI, Fikret
- Abstract
Leptomeningeal carcinomatosis (LCM) is a rare complication of gastric cancer. It usually occurs late in advanced stage of disease and is sometimes misdiagnosed as toxicity of chemotherapeutic agents. Here we report a rare case of gastric cancer that developed LCM in follow-up. A 28-year-old woman with signet ring cell gastric cancer associated with Krukenberg tumor was admitted with persistent headache, nausea, vomiting, vertigo, and diplopia. Linear appearance of contrast enhancement in cerebellar fissures and around cranial nerves was seen in magnetic resonance imaging and cerebrospinal fluid was hypercellular with numerous carcinoma cells. LMC was confirmed and treated with intrathecal methotrexate and additional whole-brain irradiation. LCM is a rare complication, but occurs more often than expected and is often misdiagnosed. If patient who is being treated for gastric cancer presents with neurological symptoms, LCM should be kept in mind. Clinical improvement can be achieved with current treatment modalities, including radiotherapy, chemotherapy, or targeted molecules.
- Subjects
BRAIN; RADIOGRAPHY; CEREBROSPINAL fluid examination; METHOTREXATE; DIAGNOSTIC errors; DIPLOPIA; HEADACHE; MAGNETIC resonance imaging; MENINGEAL cancer; NAUSEA; REFERENCE values; STOMACH tumors; TUMORS; VERTIGO; DISEASE complications; DIAGNOSIS
- Publication
Turkish Journal of Oncology / Türk Onkoloji Dergisi, 2016, Vol 31, Issue 3, p109
- ISSN
1300-7467
- Publication type
Article
- DOI
10.5505/tjo.2016.1439