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- Title
The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population.
- Authors
Li, Hongmei; Du, Zhirong; Zhang, Lin; Wu, Tong; Deng, Zhihui; Li, Jingping; Cong, Mingyu; Liu, Jicheng; Qiu, Changchun
- Abstract
Gene polymorphisms of the renin–angiotensin system are involved in the pathophysiology of hypertension. We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population. There were significant differences in the distribution of genotypes and allele frequencies at C4072T between the patients and the controls (both P < .01); patients with CC genotype had a higher risk of hypertension (odds ratio = 1.7, 95% confidence interval 1.4–2.1). The distribution of genotypes at A-6G was significantly different between patients and controls (P < .05). No other significant differences in genotypes or frequencies were observed. No association was observed between the haplotypes of AGT and hypertension. The AGT-6A and 4072C alleles are associated with susceptibility to hypertension in this population.
- Subjects
CHINA; HYPERTENSION genetics; ALLELES; ANGIOTENSINS; BLOOD pressure measurement; CHI-squared test; CONFIDENCE intervals; GENES; GENETIC polymorphisms; HYPERTENSION; POLYMERASE chain reaction; RESEARCH funding; T-test (Statistics); RENIN-angiotensin system; CASE-control method; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio
- Publication
Angiology, 2014, Vol 65, Issue 7, p614
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319713491309