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- Title
Neutrophil Gelatinase-Associated Lipocalin as an Early Marker of Contrast-Induced Nephropathy After Coronary Angiography.
- Authors
Alharazy, Sabah Mohamed; Kong, Norella; Saidin, Rashidi; Gafor, Abdul Halim Abdul; Maskon, Oteh; Mohd, Marlyn; Zakaria, Syed Zulkifli Syed
- Abstract
We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) was an early predictive biomarker of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (n = 100) undergoing coronary catheterization. Serum creatinine (SCr) levels were measured at baseline, 24 hours, and 48 hours post procedure. Serum NGAL was measured preprocedure, 4 hours, and 24 hours post procedure. The frequency of CIN was 11%. In patients with CIN, SCr achieved significance only at 48 hours (P = .006), whereas serum NGAL increased ≥25% from baseline at 24 hours in 7 of 11 patients with CIN (P = .04) but did not change in the other 4. However, serum NGAL also rose ≥25% in 12 of 89 non-CIN patients. This subgroup could have had “incipient CIN.” Serum NGAL delta value at baseline, 24 hours was superior to SCr for early diagnosis of CIN. In conclusion, serum NGAL is an early predictive biomarker for CIN.
- Subjects
MALAYSIA; CORONARY angiography; ACADEMIC medical centers; BIOMARKERS; CARRIER proteins; CONFIDENCE intervals; STATISTICAL correlation; CREATININE; ENZYME-linked immunosorbent assay; KIDNEY diseases; LONGITUDINAL method; MULTIVARIATE analysis; NEUTROPHILS; PROTEOLYTIC enzymes; RESEARCH funding; CONTRAST media; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics
- Publication
Angiology, 2014, Vol 65, Issue 3, p216
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319712474947