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- Title
Hematopoietic and Lung Platelet Biogenesis as a Prognostic Indicator in Idiopathic Pulmonary Fibrosis.
- Authors
Shigeki Saito; Chung, Cheng Han H.; Jacob, Alex; Nuradin, Nebil; Meyer, Amy E.; Haoran Yang; Kolls, Jay K.; Thannickal, Victor J.; Lasky, Joseph A.; Toshie Saito; Yao-Zhong Liu; Saito, Shigeki; Saito, Toshie; Yang, Haoran; Liu, Yao-Zhong
- Abstract
The article discusses a study which investigated whether megakaryocyte/platelet gene signatures are altered in idiopathic pulmonary fibrosis (IPF) by analysing publicly available transcriptome datasets with xCell, a novel computational method. Topics include analysis of National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) transcriptome datasets from patients with IPF and healthy control subjects, survival analysis in IDF cohort, and limitations of the study.
- Subjects
CHEST (Anatomy); IDIOPATHIC pulmonary fibrosis; LUNGS; PROGNOSIS
- Publication
American Journal of Respiratory & Critical Care Medicine, 2022, Vol 206, Issue 9, p1174
- ISSN
1073-449X
- Publication type
Article
- DOI
10.1164/rccm.202206-1195LE