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- Title
Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia.
- Authors
Li, Xian-Bin; Bo, Qi-Jing; Tian, Qing; Yang, Ning-Bo; Mao, Zhen; Zheng, Wei; Wen, Yu-Jie; Wang, Chuan-Yue
- Abstract
Background: Childhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and sensory gating in first-episode schizophrenia remains elusive. Methods: Fifty-six patients and 49 age and sex-matched healthy controls were assessed using the Childhood Trauma Questionnaire-Short Form (CTQ-SF) for CT and Positive and Negative Syndrome Scale (PANSS) for symptoms severity. Sensory gating was tested using the modified paradigm, perceived spatial separation-induced prepulse inhibition (PSS-PPI), and the perceived spatial co-location PPI (PSC-PPI or classical PPI). Results: Comparing with healthy controls, the patients had significantly higher score on sexual abuse (t = 2.729, p < 0.05), lower PSS- PPI, % (ISI = 120 ms and ISI = 60 ms) (t = − 3.089, − 4.196, p < 0.05). Univariate analysis revealed the absence of a significant correlation among CT, PPI paradigms and symptoms. However, multiple linear regression analyses demonstrated the CTQ-SF total was negatively associated with PSS PPI (ISI = 120 ms) (p = 0.018). Conclusion: The current study illustrates that the impact of CT on sensory gating in patients with first-episode schizophrenia, and thus we conclude that CT may be a risk factor to the occurrence of schizophrenia through its impact on sensory gating.
- Subjects
SCHIZOPHRENIA; WORD deafness; SEX crimes; REGRESSION analysis; GENETICS
- Publication
BMC Psychiatry, 2018, Vol 18, Issue 1, pN.PAG
- ISSN
1471-244X
- Publication type
Article
- DOI
10.1186/s12888-018-1807-7