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- Title
The role of diabetes co-morbidity for tuberculosis treatment outcomes: a prospective cohort study from Mwanza, Tanzania.
- Authors
Faurholt-Jepsen, Daniel; Range, Nyagosya; Praygod, George; Kidola, Jeremiah; Faurholt-Jepsen, Maria; Grosos Aabye, Martine; Changalucha, John; Lund Christensen, Dirk; Martinussen, Torben; Krarup, Henrik; Rinse Witte, Daniel; Beng�rd Andersen, �se; Friis, Henrik
- Abstract
Background: Due to the association between diabetes and pulmonary tuberculosis (TB), diabetes may threaten the control of TB. In a prospective cohort study nested in a nutrition trial, we investigated the role of diabetes on changes in anthropometry, grip strength, and clinical parameters over a five months follow-up period. Methods: Among pulmonary TB patients with known diabetes status, we assessed anthropometry and clinical parameters (e.g. haemoglobin) at baseline and after two and five months of TB treatment. A linear mixed-effects model (repeated measurements) was used to investigate the role of diabetes during recovery. Results: Of 1205 TB patients, the mean (standard deviation) age was 36.6 (13.0) years, 40.9% were females, 48.9% were HIV co-infected, and 16.3% had diabetes. TB patients with diabetes co-morbidity experienced a lower weight gain at two (1.3 kg, CI95% 0.5; 2.0, p = 0.001) and five months (1.0 kg, CI95% 0.3; 1.7, p = 0.007). Similarly, the increase in the level of haemoglobin was lower among TB patients with diabetes co-morbidity after two (Δ 0.6 g/dL, CI95% 0.3; 0.9 p<0.001) and five months (Δ 0.5 g/dL, CI95% 0.2; 0.9 p = 0.004) of TB treatment, respectively. Conclusion: TB patients initiating TB treatment with diabetes co-morbidity experience delayed recovery of body mass and haemoglobin, which are important for the functional recovery from disease.
- Subjects
TANZANIA; DIABETES; TUBERCULOSIS; HEMOGLOBINS; ANTHROPOMETRY
- Publication
BMC Infectious Diseases, 2012, Vol 12, Issue 1, p165
- ISSN
1471-2334
- Publication type
Article
- DOI
10.1186/1471-2334-12-165