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- Title
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
- Authors
Westphal, Sabine; Stoppe, Christian; Gruenewald, Matthias; Bein, Berthold; Renner, Jochen; Cremer, Jochen; Coburn, Mark; Schaelte, Gereon; Boening, Andreas; Niemann, Bernd; Kletzin, Frank; Roesner, Jan; Strouhal, Ulrich; Reyher, Christian; Laufenberg-Feldmann, Rita; Ferner, Marion; Brandes, Ivo F.; Bauer, Martin; Kortgen, Andreas; Stehr, Sebastian N.
- Abstract
<bold>Background: </bold>The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.<bold>Methods: </bold>We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.<bold>Results: </bold>A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10- 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10- 5 from the GWAS.<bold>Conclusions: </bold>We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.<bold>Trial Registration: </bold>The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.
- Subjects
COMPLICATIONS of cardiac surgery; ATRIAL fibrillation; MYOCARDIAL infarction; DELIRIUM; ACUTE kidney failure; STROKE; HUMAN genome
- Publication
BMC Cardiovascular Disorders, 2019, Vol 19, Issue 1, p1
- ISSN
1471-2261
- Publication type
journal article
- DOI
10.1186/s12872-019-1002-x