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- Title
Treatment of elderly patients with acute myeloid leukemia with azacitidine results in fewer hospitalization days and infective complications but similar survival compared with intensive chemotherapy.
- Authors
Lao, Zhentang; Yiu, Richard; Wong, Gee Chuan; Ho, Aloysius
- Abstract
Aims Azacitidine has been shown to prolong overall survival (OS) compared with best supportive care in elderly patients with acute myeloid leukemia ( AML) with low blast counts but it is unknown if azacitidine has a similar efficacy in patients with blast counts of >30%. It is also unknown if azacitidine is comparable to intensive chemotherapy in terms of survival and morbidity. Methods Differences between the outcomes of elderly AML patients who received intensive chemotherapy, azacitidine-based therapy or best supportive care are studied in this retrospective review. Patients 60 years or older diagnosed with AML between January 2009 and June 2011 were included. Those who passed away within less than 2 weeks of diagnosis were excluded. Results At a median follow-up of 7.2 months (range: 0.5-26.4 months), estimated median OS for patients who received azacitidine-based therapy was 9.8 months (range: 2.4-22.5 months) compared with 8.9 months (range: 0.9-26.4 months) for patients who received intensive chemotherapy ( P = 0.89). Compared with azacitidine-based therapy, intensive chemotherapy is associated with more inpatient days and episodes of febrile illness requiring inpatient stay or intravenous antibiotics. Conclusions Compared with intensive chemotherapy in elderly patients with AML, azacitidine-based therapy is associated with similar median survival but lower number of hospitalization days and infective episodes.
- Subjects
OLDER patients; ACUTE myeloid leukemia; ACUTE myeloid leukemia treatment; AZACITIDINE; HOSPITAL care; CANCER chemotherapy; PATIENTS; DISEASES
- Publication
Asia Pacific Journal of Clinical Oncology, 2015, Vol 11, Issue 1, p54
- ISSN
1743-7555
- Publication type
Article
- DOI
10.1111/ajco.12331