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- Title
Myocarditis: a defect in central immune tolerance?
- Authors
Metzger, Todd C.; Anderson, Mark S.
- Abstract
Myocarditis, or inflammation of the heart, is a potentially devastating disease that can result from both viral infection and autoimmune attack of self antigens in the heart. In the current issue of the JCI, Lv and colleagues use a genetically susceptible mouse model to show that myocarditis is a T cell-mediated autoimmune disease that occurs due to insufficient thymic negative selection of α-myosin-reactive T cells.
- Subjects
MYOCARDITIS; IMMUNOLOGICAL tolerance; CELLULAR immunity; MYOCARDIAL infarction; DISEASE susceptibility; AUTOIMMUNE diseases; T cells; DIAGNOSIS; BIOLOGICAL models; RESEARCH; MUSCLE proteins; HLA-B27 antigen; CARDIOMYOPATHIES; ANIMAL experimentation; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; MICE
- Publication
Journal of Clinical Investigation, 2011, Vol 121, Issue 4, p1251
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI57211