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- Title
Adult T cell leukemia: a tale of two T cells.
- Authors
Semmes, O. John
- Abstract
Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent for the development of an aggressive hematologic neoplasia termed adult T cell leukemia/lymphoma (ATLL). Although the virus infects T cell subsets that display either CD4 or CD8 cell surface markers, the leukemic cell is exclusively of the CD4+ subtype. In the article by Sibon et al. in this issue of the JCI, the authors demonstrate that the molecular basis for clonal expansion differs between these 2 infected T cell populations (see the related article beginning on page 974). The molecular events associated with a preleukemic state, such as genomic instability, polynucleation, and cell cycle redistribution, were only observed in CD4+ T cells. This finding provides a molecular-based mechanism for the restriction of the leukemic phenotype to the CD4+ T cell subtype.
- Subjects
ADULT T-cell leukemia; PRELEUKEMIA; LYMPHOCYTES; PRECANCEROUS conditions; HTLV diseases; LEUKEMIA; PROTEIN metabolism; BIOLOGICAL models; T cells; PHENOTYPES; T-cell lymphoma
- Publication
Journal of Clinical Investigation, 2006, Vol 116, Issue 4, p858
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI28140