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- Title
Akt1 in the cardiovascular system: friend or foe?
- Authors
O'Neill, Brian T.; Abel, E. Dale
- Abstract
Akt is an important signaling molecule that modulates many cellular processes such as cell growth, survival, and metabolism. Akt activation has been proposed as a potential strategy for increasing cardiomyocyte survival following ischemia. In mammalian cells, 3 distinct isoforms of Akt exist, but their precise roles in cardiovascular biology were previously unknown. Three separate studies published in this issue of the JCI now provide important new insight into the central role of Akt1 in the regulation of angiogenesis and the maladaptive or deleterious consequences of chronic unregulated Akt activation in the heart (see the related articles beginning on pages 2108, 2119, and 2128). Here we discuss the implications of these exciting new studies.
- Subjects
CARDIOVASCULAR diseases; HEART development regulation; REGULATION of cell growth; METABOLISM; BIOTRANSFORMATION (Metabolism); GROWTH factors; CELL metabolism; PROTEIN metabolism; ANIMAL experimentation; BIOCHEMISTRY; CELL physiology; CELLS; COMPARATIVE studies; CORONARY disease; HEART; ISOENZYMES; PHENOMENOLOGY; RESEARCH methodology; MEDICAL cooperation; MYOCARDIUM; RESEARCH; TRANSFERASES; EVALUATION research; PATHOLOGIC neovascularization
- Publication
Journal of Clinical Investigation, 2005, Vol 115, Issue 8, p2059
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI25900