We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense.
- Authors
Guise, Amanda J.; Budayeva, Hanna G.; Diner, Benjamin A.; Cristea, Ileana M.
- Abstract
Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.
- Subjects
HISTONE deacetylase; HERPESVIRUS diseases; VIRAL replicons; VIRAL replication; GENETIC transcription; EPIGENETICS; PHYSIOLOGY; VIRUSES
- Publication
Viruses (1999-4915), 2013, Vol 5, Issue 7, p1607
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v5071607