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- Title
Back Cover: Structure-Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Selectivity of Semi-synthetic Derivatives (Chem. Eur. J. 9/2017).
- Authors
Borgström, Björn; Huang, Xiaoli; Hegardt, Cecilia; Oredsson, Stina; Strand, Daniel
- Abstract
The ionophore salinomycin exerts selective activity against cancer stem cells. Synthetic strategies for modification of the directly accessible functional groups of this structure are explored, and a set of activity domains are identified by biological assays. Acylation of the C20 hydroxy group gives enhanced activity and selectivity against putative CSCs; disruption of ion coordinating motifs was not tolerated. The picture shows JIMT‐1 cells with 3D models of salinomycin approaching. More information can be found in the Full Paper by D. Strand et al. on page 2077 ff.
- Subjects
CHEMICAL structure; SALINOMYCIN; CELL-mediated cytotoxicity
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 9, p2232
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201605778