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- Title
Peripheral fat distribution versus waist circumference for predicting mortality in metabolic syndrome.
- Authors
Wu, Chen‐Jung; Kao, Tung‐Wei; Chen, Yuan‐Yuei; Yang, Hui‐Fang; Chen, Wei‐Liang; Wu, Chen-Jung; Kao, Tung-Wei; Chen, Yuan-Yuei; Yang, Hui-Fang; Chen, Wei-Liang
- Abstract
<bold>Objective: </bold>To elucidate whether the peripheral fat (PF)-combined definition of metabolic syndrome (MetS) would show a better predictive ability for cause-specific mortality than the common MetS.<bold>Methods: </bold>Data were derived from the National Health and Nutrition Examination Survey from 1999 through 2002. We investigated three types of MetS including waist circumference MetS (WCMetS), PFMetS, and PF-combined definition of MetS. The main outcome was to evaluate the predictive ability of the newly defined MetS for time to cause-specific mortality. The secondary outcomes were the relationships between the PF percentage and C-reactive protein (CRP) and homeostasis model assessment of insulin resistance (HOMA-IR) to clarify the gender discrepancy.<bold>Results: </bold>For cardiovascular mortality, the adjusted hazard ratios for WCMetS, PFMetS, and PF-combined definition MetS were 1.867, 1.742, and 2.117, respectively (all P < 0.001). A positive association between PF percentage and CRP in men and a negative correlation between PF percentage and HOMA-IR in women after adjustment for all variates were found.<bold>Conclusions: </bold>The PF-combined definition of MetS had a stronger predictive ability for all-cause and cardiovascular mortality than general MetS. Notably, the PF might have differential gender-specific health effects on cardiovascular events.
- Publication
Diabetes/Metabolism Research & Reviews, 2019, Vol 35, Issue 4, pN.PAG
- ISSN
1520-7552
- Publication type
journal article
- DOI
10.1002/dmrr.3116