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- Title
C-reactive protein and heart rate recovery in middle-aged men with severe obstructive sleep apnea.
- Authors
Chien, Meng-Yueh; Lee, Peilin; Tsai, Yuan-Feen; Yang, Pan-Chyr; Wu, Ying-Tai
- Abstract
Objective: The study aimed to evaluate whether the inflammatory marker 'high-sensitivity C-reactive protein (hsCRP)' level was associated with impaired heart rate recovery at 1 min after exercise termination (HRR-1) in middle-aged patients with severe obstructive sleep apnea (OSA). Methods: Thirty middle-aged male patients (40-64 years old) with severe OSA (apnea-hypopnea index [AHI] ≥ 30 h) and 30 subjects without OSA (AHI < 5 h), matched with age and body mass index (BMI), were recruited. All subjects underwent an overnight polysomnography and completed a symptom-limited maximal exercise test. Cardiopulmonary parameters included peak oxygen consumption (VO) and heart rate response during and immediately after exercise. Fasting blood samples were drawn for hsCRP analysis. Result: Patients with severe OSA had significantly higher hsCRP levels (0.18 vs. 0.07 mg/dl, P < 0.01), lower reduced HRR-1, peak heart rate, and VO values than those in the controls. The hsCRP levels significantly correlated with HRR-1 in the OSA group ( r = −0.69, P < 0.01) after adjustment for VO ( r = −0.66, P < 0.01). Furthermore, stepwise multiple regression analysis showed that HRR-1 and AHI were significant predictors of hsCRP levels in all participants (adjusted R = 0.53, P < 0.01). Conclusions: Blunted HRR was shown in middle-aged men with severe OSA, and it was associated with high hsCRP levels significantly.
- Subjects
C-reactive protein; INFLAMMATION; SLEEP apnea syndromes; HEART beat; BIOMARKERS; DIAGNOSIS
- Publication
Sleep & Breathing, 2012, Vol 16, Issue 3, p629
- ISSN
1520-9512
- Publication type
Article
- DOI
10.1007/s11325-011-0549-2