We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity.
- Authors
Sun, Zhonghao; Ma, Yongben; Zhang, Jiawen; Ma, Guoxu; Wu, Haifeng; Shi, Leiling; Sun, Zhaocui; Xu, Xudong
- Abstract
Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (1–4) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from Clitocybe clavipes, a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their spectroscopic data, and the ECD method. All the isolated compounds (1–4) were evaluated for their antitumor activity against three human cancer cell lines using the MTT assay. Compound 1 and 2 exhibited a significant suppression of cell viability in the Hela (IC50 = 22.8 and 19.7 μM) cell line.
- Subjects
MOIETIES (Chemistry); CELL lines; CELL survival; HELA cells; CANCER cells
- Publication
Molecules, 2023, Vol 28, Issue 14, p5456
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28145456