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- Title
Long-term results of laparoscopic liver resection for the primary treatment of hepatocellular carcinoma: role of the surgeon in anatomical resection.
- Authors
Kang, Woo-Hyoung; Kim, Ki-Hun; Jung, Dong-Hwan; Park, Gil-Chun; Kim, Seok-Hwan; Cho, Hwui-Dong; Lee, Sung-Gyu
- Abstract
<bold>Background: </bold>Liver resection is a potentially curative therapy for hepatocellular carcinoma (HCC). LLR is a newly developed and safe technique associated with shorter hospital stay, less pain, better cosmetic outcomes, and similar complication rates as open surgery; however, data on its long-term outcomes remain scarce.<bold>Methods: </bold>We retrospectively examined the clinical and follow-up data of 234 patients who underwent LLR (performed by a single surgeon in all cases) for the primary treatment of HCC between July 2007 and December 2015 at Asan Medical Center.<bold>Results: </bold>The mean patient age was 55.63 (range 31-76) years; 167 were men. The median follow-up duration was 38 (range 6-116) months. A total of 227 patients (97.0%) had Child-Turcotte-Pugh grade A disease. Of them, 167 (71.4%) underwent anatomical resections and 63 (28.6%) underwent non-anatomical partial hepatectomies. Overall survival rates were 98.3, 91.7, and 87.1%, and recurrence-free survival rates were 82.1, 67.5, and 55.3% at 1, 3, and 5 years, respectively. In Cox regression analysis, anatomical resection was a risk factor for recurrence (univariate analysis: hazard ratio [HR] 0.49; 95% confidence interval [CI] 0.31-0.75; p = 0.001; multivariate analysis: HR 0.59; 95% CI 0.38-0.94; p = 0.025).<bold>Conclusions: </bold>LLR is an acceptable primary treatment for patients with HCC with good hepatic function and with an appropriate anatomical structure, and is associated with improved prognosis. LLR can achieve lower recurrence rates through anatomical resection.
- Subjects
LAPAROSCOPIC surgery; LIVER cancer; SURGICAL complications; LIVER function tests; LIVER surgery
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2018, Vol 32, Issue 11, p4481
- ISSN
1866-6817
- Publication type
journal article
- DOI
10.1007/s00464-018-6194-0