We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Calcium stores regulate the polarity and input specificity of synaptic modification.
- Authors
Nishiyama, Makoto; Hong, Kyonsoo; Mikoshiba, Katsuhiko; Poo, Mu-ming; Kato, Kunio
- Abstract
Shows that in the CA1 region of the hippocampus reduction of postsynaptic calcium influx by partial blockade of NMDA receptors results in a conversion of long-term potentiation (LTP) to long-term depression (LTD) and a loss of input specificity normally associated with LTP, with LTD appearing at heterosynaptic inputs. Need for functional ryanodine receptors and inositol triphosphate receptors; Calcium regulating polarity and input specificity of activity-induced synaptic modification, which is essential for nervous system plasticity.
- Subjects
HIPPOCAMPUS physiology; NEUROPLASTICITY; INOSITOL phosphates; METHYL aspartate; PHYSIOLOGICAL effects of calcium
- Publication
Nature, 2000, Vol 408, Issue 6812, p584
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/35046067