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- Title
Dominant negative mutations in human PPAR gamma associated with severe insulin resistance...
- Authors
Barroso, I.; Gurnell, M.
- Abstract
Reports on two different heterozygous mutations in the ligand-binding domain of proliferator-activated receptor (PPAR) gamma in three subjects with severe insulin resistance. Development of type 2 diabetes mellitus and hypertension in subjects at an unusually early age; Germline loss-of-function mutations in PPAR gamma.
- Subjects
INSULIN resistance; TYPE 2 diabetes; DIABETES
- Publication
Nature, 1999, Vol 402, Issue 6764, p880
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/47254