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- Title
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
- Authors
Kong, Young-Yun; Yoshida, Hiroki; Sarosi, Ildiko; Hong-Lin Tan; Timms, Emma; Capparelli, Casey; Morony, Sean; Oliveira-dos-Santos, Antonio J.; Van, Gwyneth; Itie, Annick; Khoo, Wilson; Wakeham, Andrew; Dunstan, Colin R.; Lacey, David L.; Mak, Tak W.; Boyle, William J.; Penninger, Josef M.
- Abstract
Presents research on the tumor-necrosis-factor-family molecule osteoprotegerin ligand, or OPGL. Identification of OPGL as a potential osteoclast differentiation factor and regulator of interaction between T cells and dendritic cells in vitro; Severity of osteopetrosis and a defect in tooth eruption of mice; Lack of osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis; Implication of OPGL as a regulator of lymph-node organogenesis and lymphocyte development.
- Subjects
TUMOR necrosis factors; OSTEOCLASTS; T cells; OSTEOPETROSIS; LYMPH nodes
- Publication
Nature, 1999, Vol 397, Issue 6717, p315
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/16852