We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.
- Authors
Beyer, Marc; Thabet, Yasser; Müller, Roman-Ulrich; Sadlon, Timothy; Classen, Sabine; Lahl, Katharina; Basu, Samik; Zhou, Xuyu; Bailey-Bucktrout, Samantha L; Krebs, Wolfgang; Schönfeld, Eva A; Böttcher, Jan; Golovina, Tatiana; Mayer, Christian T; Hofmann, Andrea; Sommer, Daniel; Debey-Pascher, Svenja; Endl, Elmar; Limmer, Andreas; Hippen, Keli L
- Abstract
Regulatory T cells (Treg cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (Teff cell) function and gain of suppressive activity by Treg cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of Treg cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3? untranslated region. Release of SATB1 from the control of Foxp3 in Treg cells caused loss of suppressive function, establishment of transcriptional Teff cell programs and induction of Teff cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining Treg cell functionality.
- Subjects
T cells; CELL differentiation; HOMEOSTASIS; GENETIC repressors; GENETIC transcription; CHROMATIN; CYTOKINES; GENE expression; PHENOTYPES
- Publication
Nature Immunology, 2011, Vol 12, Issue 9, p898
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2084