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- Title
Immunohistochemical Analysis of Steroid Hormone Receptors and Structural Proteins in Skin: Effects of Aging and Hormone Status.
- Authors
Reed, Gregory A.; Tawfik, Ossama; Casparian, J. Michael
- Abstract
Reports describing beneficial effects of estrogens on skin structure suggest that skin may contain estrogen receptors (ERs). The present study was designed to determine the presence of these receptors and related proteins in skin from the dorsal forearm and buttocks of 12 pre menopausal and 13 post-menopausal subjects who were not taking any hormonal supplements. Fixed, sectioned samples were stained with hematoxylin and eosin for general characterization with Verhoeff-van Gieson elastic stain, and with immunohistochemical staining for ERs. progesterone receptors, and fibronectin. The results showed that fibronectin and elastin fibers were present and were more abundant in sun-exposed skin. In contrast, ERs and progesterone receptors were not found in skin. The absence of ERs and progesterone receptors in all samples weakens the hypothesis that estrogen exerts direct receptor-mediated actions on skin.
- Subjects
STEROIDS; HORMONE receptors; AGING; ESTROGEN; PROGESTERONE receptors; MENOPAUSE
- Publication
Journal of Applied Research, 2005, Vol 5, Issue 2, p371
- ISSN
1537-064X
- Publication type
Article