We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Risk of cervical dysplasia among human papillomavirus-infected women in Korea: a multicenter prospective study.
- Authors
Yoon Park; Tae-Jin Kim; Chang-Sun Hwang; Chi Heum Cho; Dae Hoon Jeong; Seok Ju Seong; Jae-Kwan Lee; Sooyoung Hur; Mee-Kyung Kee; Jaehyun Seong; Ki, Moran
- Abstract
Objective: Human papillomavirus (HPV) infection is the most important risk factor for cervical cancer, which progresses from precursor lesions with no symptom if left untreated. We compared the risk of cervical dysplasia among HPV-positive Korean women based on HPV types and infection patterns. Methods: We observed participants of a 5-year multicenter prospective cohort study, comprising HPV-positive women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion of the cervix at their enrollment. Follow-ups, comprising cytology and HPV DNA testing results, were included in the final analysis. Incidence was calculated for each infection pattern (persistent infection, incidental infection, and clearance). To investigate cervical dysplasia risk, we used Cox proportional hazard models adjusted for variables that were significantly different among infection patterns. From April 2010 to September 2017, 71 of 1,027 subjects developed cervical dysplasia more severe than high-grade squamous intraepithelial lesion of the cervix. Results: Of these 71 subjects, persistent infection, incidental infection, and clearance were noted in 30, 39, and 2 individuals, respectively. Based on changes in DNA results during follow-up, cumulative incidence was 27.2%, 10.4%, and 0.5% for persistent infection, incidental infection, and clearance, respectively. Compared to clearance, the adjusted hazard ratios for cervical dysplasia were 51.6 and 24.1 for persistent and incidental infections, respectively (p<0.001). Conclusion: Individuals persistently infected with the same HPV types during the follow-up period had the highest risk of severe cervical dysplasia. Hence, it is necessary to monitor HPV types and infection patterns to prevent severe cervical precancerous lesions.
- Subjects
SOUTH Korea; CERVICAL intraepithelial neoplasia; DISEASE risk factors; PRECANCEROUS conditions; PAPILLOMAVIRUS diseases; CANCER risk factors; CERVICAL cancer; WOMEN
- Publication
Journal of Gynecologic Oncology, 2019, Vol 30, Issue 3, p1
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2019.30.e50