We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Phase II Study of Concurrent Chemoradiotherapy at the Dose of 50.4 Gy with Elective Nodal Irradiation for Stage II–III Esophageal Carcinoma.
- Authors
Kato, Ken; Eguchi Nakajima, Takako; Ito, Yoshinori; Katada, Chikatoshi; Ishiyama, Hiromichi; Tokunaga, Shin-ya; Tanaka, Masahiro; Hironaka, Shuichi; Hashimoto, Takayuki; Ura, Takashi; Kodaira, Takeshi; Yoshimura, Ken-ichi
- Abstract
Objective Definitive chemoradiotherapy is one of the curative options for resectable esophageal squamous cell carcinoma with organ preservation. We evaluated the efficacy and toxicity of radiotherapy at a dose of 50.4 Gy concurrent with chemotherapy for Stage II–III esophageal cancer. Methods Esophageal cancer patients with clinical Stage II–III (T1N1M0 or T2-3N0-1M0) were eligible. Radiotherapy was administered to a total dose of 50.4 Gy with elective nodal irradiation of 41.4 Gy. Concurrent chemotherapy comprised two courses of 5-fluorouracil (1000 mg/m2/day) on days 1–4 and 2-h infusion of cisplatin (75 mg/m2) on Day 1; this was repeated every 4 weeks. Two courses of 5-fluorouracil with cisplatin were added. Results Fifty-one patients were enrolled in the study from June 2006 to May 2008. The characteristics of the 51 patients enrolled were as follows: median age 64 years; male/female, 45/6; performance status 0/1, 32/19 patients; Stage IIA/IIB/III, 9/20/22 patients, respectively. A complete response was achieved in 36 patients (70.6%). The 1- and 3-year overall survival rate was 88.2 and 63.8%, respectively. The median 1- and 3-year progression-free survival rate was 66.7% (80% CI: 57–74%) and 56.6% (80% CI: 47.1–64.9%), respectively. Acute toxicities included Grade 3/4 anorexia (45%), esophagitis (35%) and febrile neutropenia (20%). Eight patients (15.6%) underwent salvage surgery due to residual or recurrent disease. There were no deaths related to salvage surgery. Conclusion Chemoradiation therapy at a dose of 50.4 Gy with elective nodal irradiation is promising with a manageable tolerability profile in esophageal cancer patients.
- Publication
Japanese Journal of Clinical Oncology, 2013, Vol 43, Issue 6, p608
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyt048