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- Title
Dermatofibrosarcoma Protuberans Metastasizing toCavernous Sinuses and Lungs: a Case Report.
- Authors
Zorlu, Faruk; Yildiz, Ferah; Ertoy, Dilek; Atahan, I. Lale; Erden, Esra
- Abstract
Dermatofibrosarcoma protuberans (DFSP) is a locallyaggressive tumor with a low potential for distant metastases. Wereport a 22-year-old female patient with a typical cutaneous DFSPwho developed five local recurrences followed by left cavernoussinus metastasis at the eighth year and right cavernous sinus andlung metastases at the ninth year. In each local recurrence the tumorshowed histological signs of progression as being more cellular,having higher mitotic index and being aggressively invasive throughthe underlying soft tissues. The histopathological evaluationof the metastatic tumor resected from the left cavernous sinus revealed dedifferentiationfrom low-grade DFSP to higher grade fibrosarcomatous morphology.Immunohistochemical studies of the primary tumor and alsothe recurrent and metastatic tumors showed diffuse CD34 positivityin all specimens and p53 positivity was detected in the metastatictumor resected from left cavernous sinus.
- Publication
Japanese Journal of Clinical Oncology, 2001, Vol 31, Issue 11, p557
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hye117