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- Title
Modification of Chemo-radiosensitivity of a Human Lung Cancer Cell Line by Introduction of the Glutathione S-transferase φ Gene.
- Authors
Miyara, Hajime; Hida, Toyoaki; Nishida, Keiko; Takahashi, Toshitada; Sugiura, Takahiko; Ariyoshi, Yutaka; Morishita, Munehiko; Takahashi, Takashi; Ueda, Ryuzo
- Abstract
Recent studies have suggested that glutathione S-transferase φ (GST-φ) may play a role in determining tumor sensitivities to cytotoxic drugs. In order to better understand the role of this enzyme in chemo- and/or radioresistance of lung cancer cells, we examined whether introduction of GST-φ cDNA into a chemo- and radiosensitive lung cancer cell line altered its sensitivities to various chemotherapeutic agents and/or ionizing radiation, which are often used in the management of lung cancers. Modestly increased resistance of the GST-φ trarisfectants preferentially to sublethal damage caused by ionizing radiation as well as to adriamycin (ADM) was observed. In contrast, resistances to cisplatin (CODP), etoposide (VP-16), irinotecan hydrochloride (CPT-11) and paclitaxel were virtually unaltered. These results suggest that GST-φ may not play a major role in chemo- and radioresistance of lung cancers, although it could afford selective and limited protection against ADM- and ionizing radiation-induced damage.
- Publication
Japanese Journal of Clinical Oncology, 1996, Vol 26, Issue 1, p1
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/oxfordjournals.jjco.a023171