We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Investigation of the effect of tDCS on resting state network connectivity in MTLE.
- Authors
Küçük, Zeynep; Şahin, Erdi; Kurt, Elif; Eryürek, Kardelen; Bebek, Nerses; Baykan, Betül; Demiralp, Tamer; Karamürsel, Sacit
- Abstract
Objective: The purpose of this preliminary study is to examine the effect of tDCS on resting state network connectivity in patients diagnosed with mesial temporal lobe epilepsy (mTLE) in order to develop a new method to inhibit epileptic seizures. Methods: The present study analyzed the resting state functional MRI data from a homogenous group of mTLE patients with left hippocampal sclerosis using seed-based correlations. Nine drug-resistant unoperated patients with left mTLE (mean age 36.8±9.95) participated in this study. Resting fMRI scans were acquired before and after 2 mA cathodal tDCS lasting 20 min over the temporal region (T3) while anode electrode was placed over supraorbital region. Pre- and post-tDCS resting state fMRI data were recorded with 3T MRI scanner and SPM8 was used for data preprocessing. Functional connectivity analyses were conducted with the CONN-fMRI toolbox and 62 seeds were selected. The corrected results with significant cluster level of p <0.05 FDR have been calculated. Results: Increased functional connectivity following cathodal tDCS was apparent between left supramarginal gyrus (anterior division) and right posterior cerebellum (pFDR=0.03), left frontoparietal network and left posterior cerebellum (pFDR=0.03). While an increased correlation was also observed between left insula and left inferior frontal operculum (pFDR=0.005), there was decreased correlation between left temporal fusiform cortex and left inferior frontal gyrus (pFDR=0.03). Conclusion: Increased connectivity between cerebellum and the fronto-parietal network after tDCS may indicate a positive finding to control the seizures. Increased connectivity between the left insula and left inferior frontal operculum may also be important in controlling seizures by providing a feedback mechanism. Furthermore, increased connectivity between the left anterior supramarginal gyrus and right posterior cerebellum could be speculated to have a positive value on cognitive functions. On the other hand decreased connectivity between the left temporal fusiform cortex and left inferior occipital gyrus may be evaluated in regard to clinical symptoms.
- Subjects
TEMPORAL lobe epilepsy; EPILEPSY; FUNCTIONAL magnetic resonance imaging
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2018, Vol 12, Issue Supp1, pS53
- ISSN
1307-8798
- Publication type
Abstract