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- Title
Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis.
- Authors
Cesar Machado, Marcel Cerqueira; Mendonça Coelho, Ana Maria; Carneiro D'Albuquerque, Luiz Augusto; Jancar, Sonia
- Abstract
Elderly patients show increased incidence of multiple organ dysfunction in acute pancreatitis possibly due to bacterial translocation. This is associated with increased susceptibility to infections in older people. Several reports have related this increased susceptibility to a proinflammatory status called inflammaging, which decreases the capacity of the immunological system to respond to antigens. Cellular senescence also contributes to this low-grade chronic inflammation in older subjects. We discuss here the effect of ageing on systemic inflammation, focusing on that induced by acute pancreatitis and some of the mechanisms involved. It is important to understand the immunological changes in the elderly to adjust treatment strategies in order to reduce the morbidity and mortality associated with acute pancreatitis and other conditions that lead to systemic inflammation.
- Publication
International Journal of Inflammation, 2012, p1
- ISSN
2090-8040
- Publication type
Journal Article
- DOI
2012/270319