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- Title
Prioritizing single-nucleotide polymorphisms and variants associated with clinical mastitis.
- Authors
Suravajhala, Prashanth; Benso, Alfredo
- Abstract
Next-generation sequencing technology has provided resources to easily explore and identify candidate single-nucleotide polymorphisms (SNPs) and variants. However, there remains a challenge in identifying and inferring the causal SNPs from sequence data. A problem with different methods that predict the effect of mutations is that they produce false positives. In this hypothesis, we provide an overview of methods known for identifying causal variants and discuss the challenges, fallacies, and prospects in discerning candidate SNPs. We then propose a three-point classification strategy, which could be an additional annotation method in identifying causalities.
- Subjects
SINGLE nucleotide polymorphisms; GENETIC polymorphisms; MASTITIS; BREAST diseases; POPULATION genetics; AMPLIFIED fragment length polymorphism
- Publication
Advances & Applications in Bioinformatics & Chemistry, 2017, Vol 10, p57
- ISSN
1178-6949
- Publication type
Article
- DOI
10.2147/AABC.S123604