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- Title
Expressão de genes relacionados à função adrenocortical no estado de caquexia neoplásica.
- Authors
de Angelis Scripes, Nicole; Macioszek, Marcelo Abbá; Bahls, Larissa Danielle; Aoki, Mateus Nóbrega; Watanabe, Maria Angelica Ehara; Mazzuco, Tânia Longo
- Abstract
The adrenal gland plays a crucial role in the neuroendocrine response, especially in situations where homeostasis is disturbed. In the neoplastic cachexia process, there is homeostasis impairment by nutritional and metabolic alterations of advanced-stage cancer, involving hypothalamus-pituitary-adrenal axis response. In this assignment, an experimental model of cachexia induced by Walker-256 tumor was performed in Wistar rats. Animals (n=4) were sacrificed 10 days after inoculation of tumor cells, and the adrenal glands were excised. The RNA was isolated for the study of gene expression related to the steroidogenesis control by semi-quantitative RT-PCR. Data analysis showed a significant reduced expression of MC2R (melancortin type 2 receptor), 3βHSD I (3-beta-hydroxysteroid dehydrogenase type I) and TSPO (translocator protein) genes in animals with neoplastic cachexia (P =0.037, 0.0097 and 0.052, respectively), revealing adrenal cortex failure.
- Subjects
ADRENOCORTICAL hormones; NEUROENDOCRINE cells; ADRENAL glands; CACHEXIA; HYPOTHALAMUS; ADRENAL cortex; GENE expression; POLYMERASE chain reaction; HOMEOSTASIS; DATA analysis
- Publication
Acta Scientiarum: Health Sciences, 2009, Vol 31, Issue 2, p133
- ISSN
1679-9291
- Publication type
Article
- DOI
10.4025/actascihealthsci.v31i2.6759