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- Title
The successful search for genetic loci associated with depression.
- Authors
Rivera, Margarita; McGuffin, Peter
- Abstract
Major depressive disorder is among the leading causes of disease burden and disability, as well as a major public health concern worldwide. Despite its substantial heritability, no robustly replicated genetic risk loci had been found until recently. Now, a new study has identified, and replicated, two variants associated with an increased risk for this disorder. The success of this study appears to lie in the use of low-coverage sequencing, instead of microarrays, and in minimizing phenotypic and genetic heterogeneity.
- Subjects
SEXISM; GENETIC code; GENE expression; HEALTH risk assessment; HEALTH status indicators
- Publication
Genome Medicine, 2015, Vol 7, Issue 1, p1
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/s13073-015-0217-4