We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Phosphine‐Catalyzed [4+3] Annulation Reaction of Indole Derivatives with MBH Carbonates: A Facile Access to Indole‐1,2‐fused 1,4‐Diazepinones and Azepines.
- Authors
Zhu, Yannan; Jiang, Haoran; Wang, Yi‐Ning
- Abstract
Comprehensive Summary: A phosphine‐catalyzed [4+3] annulation between dinucleophilic indole derivatives and Morita−Baylis−Hillman (MBH) carbonates was discovered by using the N1 and N4′/C4′ nucleophilicities of the indole precursors, in which indoles act as four atom synthons. This protocol provides an efficient and facile access to indole‐1,2‐fused 1,4‐diazepinones and azepines in good to high yields in one step, which illustrates potential synthetic utilities in drug discovery.
- Subjects
ANNULATION; DRUG discovery; CARBONATES; INDOLE derivatives; AZEPINES; INDOLE compounds; NUCLEOPHILIC reactions
- Publication
Chinese Journal of Chemistry, 2024, Vol 42, Issue 3, p271
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202300505