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- Title
On the horizon: Optical imaging for cutaneous squamous cell carcinoma.
- Authors
de Boer, Esther; Moore, Lindsay S.; Warram, Jason M.; Huang, Conway C.; Brandwein–Gensler, Margaret S.; van Dam, Gooitzen M.; Rosenthal, Eben L.; Schmalbach, Cecelia E.; Eisele, David W.
- Abstract
Background Surgical resection with negative margins remains the standard of care for high-risk cutaneous squamous cell carcinoma (SCC). However, surgical management is often limited by poor intraoperative tumor visualization and inability to detect occult nodal metastasis. The inability to intraoperatively detect microscopic disease can lead to additional surgery, tumor recurrence, and decreased survival. Methods A comprehensive literature review was conducted to identify studies incorporating optical imaging technology in the management of cutaneous SCC (January 1, 2000-December 1, 2014). Results Several innovative optical imaging techniques, Raman spectroscopy, confocal microscopy, and fluorescence imaging, have been developed for intraoperative surgical guidance. Fifty-seven studies review the ability of these techniques to improve cutaneous SCC localization at the gross and microscopic level. Conclusion Significant advances have been achieved with real-time optical imaging strategies for intraoperative cutaneous SCC margin assessment and tumor detection. Optical imaging holds promise in improving the percentage of negative surgical margins and in the early detection of micrometastatic disease. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2204-E2213, 2016
- Subjects
SKIN cancer; CANCER treatment; SQUAMOUS cell carcinoma; DIAGNOSTIC imaging research; ONCOLOGIC surgery; LYMPH nodes
- Publication
Head & Neck, 2016, Vol 38, pE2204
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24079