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- Title
Erythropoietin, progenitors, and repair.
- Authors
Aydin, Z.; Duijs, J.; Bajema, I. M.; van Zonneveld, A. J.; Rabelink, T. J.
- Abstract
The erythropoietin–erythropoietin-receptor (EPO–EPO-R) system has recently been identified as an important cellular survival pathway. Its presence has also been demonstrated in the kidney and identified as a therapeutic target to prevent loss of renal function. Part of the protective effects may be related to the action of erythropoietin on endothelial function and expansion of endothelial progenitor cells. This paper reviews current evidence for involvement of these mechanisms in EPO-mediated renoprotection.Kidney International (2007) 72, S16–S20; doi:10.1038/sj.ki.5002483
- Subjects
ERYTHROPOIETIN; CELL receptors; KIDNEYS; RENAL circulation; ENDOTHELIUM
- Publication
Kidney International Supplement, 2007, Issue 107, pS16
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1038/sj.ki.5002483