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- Title
Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid.
- Authors
Koethe, Dagmar; Schreiber, Daniela; Giuffrida, Andrea; Mauss, Christian; Faulhaber, Johannes; Heydenreich, Bernd; Hellmich, Martin; Graf, Rudolf; Klosterkötter, Joachim; Piomelli, Daniele; Leweke, F. Markus
- Abstract
This study investigated the role of two fatty acid ethanolamides, the endogenous cannabinoid anandamide and its structural analog oleoylethanolamide in sleep deprivation of human volunteers. Serum and cerebrospinal fluid (CSF) samples were obtained from 20 healthy volunteers before and after a night of sleep deprivation with an interval of about 12 months. We found increased levels of oleoylethanolamide in CSF ( P = 0.011) but not in serum ( P = 0.068) after 24 h of sleep deprivation. Oleoylethanolamide is an endogenous lipid messenger that is released after neural injury and activates peroxisome proliferator-activated receptor-α (PPAR-α) with nanomolar potency. Exogenous PPAR-α agonists, such as hypolipidemic fibrates and oleoylethanolamide, exert both neuroprotective and neurotrophic effects. Thus, our results suggest that oleoylethanolamide release may represent an endogenous neuroprotective signal during sleep deprivation.
- Subjects
SLEEP deprivation; INSOMNIA; CEREBROSPINAL fluid; FATTY acids; SLEEP disorders
- Publication
Journal of Neural Transmission, 2009, Vol 116, Issue 3, p301
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-008-0169-6