We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Tumor-Infiltrating Lymphocytes in Breast Cancer: Evaluating Interobserver Variability, Heterogeneity, and Fidelity of Scoring Core Biopsies.
- Authors
Khoury, Thaer; Peng, Xuan; Yan, Li; Wang, Dan; Nagrale, Vidya
- Abstract
<bold>Objectives: </bold>The aims were to evaluate breast cancer (BC) tumor-infiltrating lymphocytes (TILs) interobserver variability, heterogeneity, and the fidelity of scoring TILs in core needle biopsy (CNB).<bold>Methods: </bold>Matching CNB and two full-face sections (FFSs) of BC cases (n = 100) were independently reviewed by two pathologists. Percentage of stromal lymphocytes (TIL-str) and intratumoral lymphocytes (iTu-Ly) were recorded.<bold>Results: </bold>The weighted κ values for the degree of agreement between both raters were 0.53 to 0.71. However, there was a slight improvement in the interobserver variability for TIL-str and slight decline in iTu-Ly when ER+/HER2- cases were excluded. The intraclass correlation coefficient for FFS1 vs FFS2 was 0.91 for TIL-str and 0.96 for iTu-Ly. Spearman correlation coefficient for CNB vs FFS1/FFS2 was 0.81 for TIL-str and 0.79 for iTu-Ly.<bold>Conclusions: </bold>We conclude that the agreement in TILs scoring between the raters is acceptable. Caution should be practiced when scoring iTu-Ly in CNBs.
- Subjects
BREAST cancer; LYMPHOCYTES; CORE needle biopsy; BREAST tumor diagnosis; PROTEIN metabolism; BREAST tumors; CELL receptors; NEEDLE biopsy; RESEARCH evaluation; RESEARCH bias
- Publication
American Journal of Clinical Pathology, 2018, Vol 150, Issue 5, p441
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1093/ajcp/aqy069