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- Title
Protein Partners of α-Synuclein in Health and Disease.
- Authors
Lassen, Louise Berkhoudt; Reimer, Lasse; Ferreira, Nelson; Betzer, Cristine; Jensen, Poul Henning
- Abstract
α-synuclein is normally situated in the nerve terminal but it accumulates and aggregates in axons and cell bodies in synucleinopathies such as Parkinson's disease. The conformational changes occurring during α-synucleins aggregation process affects its interactions with other proteins and its subcellular localization. This review focuses on interaction partners of α-synuclein within different compartments of the cell with a focus on those preferentially binding aggregated α-synuclein. The aggregation state of α-synuclein also affects its catabolism and we hypothesize impaired macroautophagy is involved neuronal excretion of α-synuclein species responsible for the prion-like spreading of α-synuclein pathology.
- Subjects
SYNUCLEINS; CARRIER proteins; NEURODEGENERATION; PROTEIN-protein interactions; PROTEOMICS
- Publication
Brain Pathology, 2016, Vol 26, Issue 3, p389
- ISSN
1015-6305
- Publication type
Article
- DOI
10.1111/bpa.12374